Manfred Jung Selected Research

Histone Deacetylases (Histone Deacetylase)

1/2022	First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement.
1/2021	Hypoxia-activated KDAC inhibitor: Taking a breath from untargeted therapy.
1/2021	The potential for histone deacetylase (HDAC) inhibitors as cestocidal drugs.
2/2018	Identification of Bichalcones as Sirtuin Inhibitors by Virtual Screening and In Vitro Testing.
1/2018	The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines.
12/2017	Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity.
12/2017	Structure-Activity Relationship of Propargylamine-Based HDAC Inhibitors.
8/2017	Isophthalic Acid-Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni.
1/2016	Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies.
1/2016	Targeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases.

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Manfred Jung Research Topics

Disease

79	Neoplasms (Cancer) 01/2022 - 07/2002
10	Schistosomiasis (Bilharziasis) 12/2021 - 01/2013
8	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 01/2008
7	Prostatic Neoplasms (Prostate Cancer) 01/2019 - 01/2012
6	Breast Neoplasms (Breast Cancer) 01/2015 - 09/2007
5	Neuroblastoma 01/2022 - 04/2007
5	Carcinogenesis 01/2020 - 01/2009
4	Neglected Diseases 01/2022 - 01/2013
4	Parasitic Diseases (Parasitic Disease) 12/2021 - 07/2015
4	Inflammation (Inflammations) 10/2019 - 02/2015
4	Leukemia 09/2012 - 12/2003
3	Neoplasm Metastasis (Metastasis) 01/2020 - 12/2014
3	Squamous Cell Carcinoma (Epidermoid Carcinoma) 10/2019 - 06/2004
3	Pathologic Processes 01/2012 - 10/2010
2	Hypoxia (Hypoxemia) 01/2021 - 01/2019
2	Medulloblastoma 01/2018 - 04/2007
2	Rhabdoid Tumor (Rhabdoid Tumors) 06/2013 - 04/2007
2	Metabolic Diseases (Metabolic Disease) 12/2012 - 01/2008
2	Melanoma (Melanoma, Malignant) 03/2008 - 12/2003
2	Experimental Melanoma 03/2008 - 12/2003
1	Heart Failure 01/2022
1	Cysticercosis 01/2022
1	Echinococcosis (Hydatid Cysts) 01/2022
1	Diabetic Nephropathies (Diabetic Nephropathy) 04/2021
1	Idiopathic Pulmonary Fibrosis 01/2021
1	Prader-Willi Syndrome (Syndrome, Prader-Willi) 11/2020
1	Imprinting Disorders 11/2020
1	Peripheral Nervous System Diseases (PNS Diseases) 01/2020
1	Huntington Disease (Huntington's Disease) 01/2020
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/2020
1	Alzheimer Disease (Alzheimer's Disease) 04/2019
1	Multiple Myeloma 10/2018

Drug/Important Bio-Agent (IBA)

24	Pharmaceutical PreparationsIBA 01/2022 - 01/2009
20	Histone Deacetylases (Histone Deacetylase)IBA 01/2022 - 06/2004
20	Histones (Histone)IBA 11/2020 - 05/2007
17	Histone Deacetylase InhibitorsIBA 11/2020 - 06/2004
15	EnzymesIBA 01/2021 - 03/2008
12	SirtuinsIBA 01/2022 - 01/2008
12	Lysine (L-Lysine)FDA Link 01/2021 - 07/2012
9	Proteins (Proteins, Gene)FDA Link 05/2021 - 01/2009
9	Biological ProductsIBA 01/2021 - 09/2007
8	Praziquantel (Biltricide)FDA Link 12/2021 - 01/2013
5	ChromatinIBA 05/2021 - 01/2009
5	MethyltransferasesIBA 11/2020 - 01/2012
5	TubulinIBA 08/2020 - 03/2008
5	Histone DemethylasesIBA 11/2019 - 12/2012
5	AndrogensIBA 01/2019 - 01/2012
5	Vorinostat FDA Link 10/2018 - 06/2004
4	Histone MethyltransferasesIBA 11/2020 - 01/2009
4	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 06/2004
4	Sirtuin 2IBA 02/2016 - 01/2015
3	Sirtuin 1IBA 01/2020 - 09/2012
3	Androgen Receptors (Androgen Receptor)IBA 01/2019 - 12/2012
3	Oxidoreductases (Dehydrogenase)IBA 01/2018 - 12/2003
3	Phosphotransferases (Kinase)IBA 12/2016 - 01/2014
3	Hormones (Hormone)IBA 09/2013 - 08/2007
2	ZincIBA 01/2022 - 01/2016
2	ProdrugsIBA 01/2021 - 11/2007
2	Small Interfering RNA (siRNA)IBA 10/2019 - 06/2014
2	Messenger RNA (mRNA)IBA 12/2018 - 07/2008
2	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2018 - 06/2013
2	Antineoplastic Agents (Antineoplastics)IBA 01/2018 - 07/2012
2	Cisplatin (Platino)FDA LinkGeneric 01/2017 - 01/2017
2	Transcription Factors (Transcription Factor)IBA 01/2016 - 07/2015
2	Protein Kinase CIBA 12/2014 - 01/2014
2	posaconazole FDA Link 10/2013 - 09/2012
2	Group III Histone DeacetylasesIBA 12/2012 - 03/2012
2	DepsipeptidesIBA 08/2012 - 06/2004
2	theasinensin AIBA 03/2008 - 04/2007
2	Coenzyme A (CoA)IBA 03/2008 - 12/2003
2	FarnesolIBA 03/2008 - 12/2003
2	trichostatin A (A 300)IBA 03/2008 - 06/2004
1	AnthelminticsIBA 01/2022
1	Glucose (Dextrose)FDA LinkGeneric 04/2021
1	PyrrolesIBA 12/2020
1	Therapeutic UsesIBA 11/2020
1	GTP-Binding Proteins (G-Protein)IBA 11/2020
1	pitolisantIBA 11/2020
1	Histamine H3 Receptors (Histamine H3 Receptor)IBA 11/2020
1	6- chloro- 2,3,4,9- tetrahydro- 1H- carbazole- 1- carboxamideIBA 01/2020
1	TriazolesIBA 01/2020
1	Histone Deacetylase 6IBA 01/2020
1	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 01/2019
1	enzalutamideIBA 01/2019
1	Deferasirox FDA Link 01/2019
1	PCI 34051IBA 12/2018
1	CrizotinibIBA 12/2018
1	Bortezomib (Velcade)FDA Link 10/2018
1	cinnamic acidIBA 10/2018
1	Dexamethasone (Maxidex)FDA LinkGeneric 10/2018
1	CarbamatesIBA 09/2018
1	NAD (NADH)IBA 02/2018
1	Flavin-Adenine Dinucleotide (FAD)IBA 01/2018
1	Monoamine Oxidase (MAO)IBA 01/2018
1	CaspasesIBA 01/2018

Therapy/Procedure

18	Therapeutics 01/2021 - 12/2005
6	Drug Therapy (Chemotherapy) 01/2020 - 11/2007
2	Chemoprevention 10/2008 - 03/2008
1	Castration 01/2019
1	Caloric Restriction 01/2018